Technology Process of (5E,7E,9E)-11-Cyclohexylidene-4-ethyl-undeca-5,7,9-trienal
There total 8 articles about (5E,7E,9E)-11-Cyclohexylidene-4-ethyl-undeca-5,7,9-trienal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-di-tert-butyl-4-methyl-phenol; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
In
dichloromethane;
at -78 - 23 ℃;
DOI:10.1016/S0040-4039(00)85737-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) LDA / 2.) THF, -40 deg C to room temp.
2: 92 percent / LiAlH4 / diethyl ether / 0 °C
3: (C6H5)3PBr2 / acetonitrile / 0 °C
4: toluene / 110 °C
5: KO-t-Bu / 1,2-dimethoxy-ethane / 1.5 h / 0 °C
6: 1.) 9-BBN, BHT; 2.) NaOH, H2O2, BHT / 1.) THF, 0 deg C
7: 80 percent / TFAA, DMSO, diisopropylethylamine, BHT / CH2Cl2 / -78 - 23 °C
With
sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; 2,6-di-tert-butyl-4-methyl-phenol; potassium tert-butylate; dihydrogen peroxide; dimethyl sulfoxide; triphenylphosphine dibromide 1:1 addition complex; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium diisopropyl amide;
In
1,2-dimethoxyethane; diethyl ether; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)85737-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene / 110 °C
2: KO-t-Bu / 1,2-dimethoxy-ethane / 1.5 h / 0 °C
3: 1.) 9-BBN, BHT; 2.) NaOH, H2O2, BHT / 1.) THF, 0 deg C
4: 80 percent / TFAA, DMSO, diisopropylethylamine, BHT / CH2Cl2 / -78 - 23 °C
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; 2,6-di-tert-butyl-4-methyl-phenol; potassium tert-butylate; dihydrogen peroxide; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
In
1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)85737-8
