dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate

Base Information

• Chemical Name: dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate
• CAS No.: 897650-19-0
• Molecular Formula: C₁₄H₂₀NO₆P
• Molecular Weight: 329.29
• Mol file: 897650-19-0.mol

Synonyms:dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate

Chemical Property of dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate

There total 2 articles about dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

dimethyl 4-amino-3-oxobutylphosphonate + benzyl chloroformate (501-53-1,94274-21-2) → dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate (897650-19-0)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 12h;

DOI:10.1021/jo060364v

Reference yield:

dimethyl 4-phthalimido-3-oxobutylphosphonate (897650-17-8) → dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate (897650-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / methanol / 24 h / 20 °C

2: 67 percent / Et₃N / CHCl₃ / 12 h / 20 °C

With triethylamine; hydrazine; In methanol; chloroform;

DOI:10.1021/jo060364v

Reference yield:

dimethyl 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate (897650-19-0) → disodium 4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 3 h

2: H₂O; NaHCO₃ / acetone / 1 h

With water; sodium hydrogencarbonate; In dichloromethane; acetone;

DOI:10.1021/jo060364v

upstream raw materials:

benzyl chloroformate

dimethyl 4-phthalimido-3-oxobutylphosphonate