4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

Base Information

Chemical Name:4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene
CAS No.:101697-30-7
Molecular Formula:C₁₆H₁₃ClF₁₂O₂
Molecular Weight:500.712
Hs Code.:

Synonyms:4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

Chemical Property:

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Technology Process of 4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

There total 4 articles about 4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-bromo-4-tert-butyl-2-<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>aniline

: 101697-30-7
4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent

2: 44 percent / n-BuLi / diethyl ether; tetrahydrofuran

3: 22 g / H⁽¹⁺⁾

4: 1.) conc. HCl, NaNO₂, conc. H₂SO₄, 2.) Cu / 1.) acetic acid, H₂O, R_.T_., 2 h, 2.) 100 deg C, 10 h

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen cation; copper; sodium nitrite; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00273a041

Reference yield:

: 101697-23-8
1,4-dihydro-8-bromo-6-tert-butyl-2,2-dimethyl-4,4-bis(trifluoromethyl)-2H-<3,1>benzoxazine

: 101697-30-7
4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / n-BuLi / diethyl ether; tetrahydrofuran

2: 22 g / H⁽¹⁺⁾

3: 1.) conc. HCl, NaNO₂, conc. H₂SO₄, 2.) Cu / 1.) acetic acid, H₂O, R_.T_., 2 h, 2.) 100 deg C, 10 h

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen cation; copper; sodium nitrite; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00273a041

Reference yield:

: 101697-25-0
4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>aniline

: 101697-30-7
4-tert-butyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>chlorobenzene

Guidance literature:: With hydrogenchloride; sulfuric acid; copper; sodium nitrite; Yield given. Multistep reaction; 1.) acetic acid, H₂O, R_.T_., 2 h, 2.) 100 deg C, 10 h;
DOI:10.1021/ja00273a041