3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester
• CAS No.: 114943-03-2
• Molecular Formula: C₂₀H₂₆N₄O₄S
• Molecular Weight: 418.517

Synonyms:3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester

Chemical Property of 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester

There total 2 articles about 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 3-thiophene-2-carboxylate (110164-57-3) + 4-(3-methoxyphenyl) piperazine hydrochloride (16015-70-6,6968-76-9) → 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester (114943-03-2)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; for 60h; Heating;

DOI:10.1021/jm00117a019

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → 3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester (114943-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / toluene / 3 h / Heating

2: 58 percent / NaHCO₃, NaI / tetrahydrofuran / 60 h / Heating

With sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; toluene;

DOI:10.1021/jm00117a019

Reference yield:

3-(3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-thiophene-2-carboxylic acid methyl ester (114943-03-2) → 3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-thieno[3,2-d]pyrimidine-2,4-dione (114942-99-3)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Yield given; Heating;

DOI:10.1021/jm00117a019

upstream raw materials:

methyl 3-thiophene-2-carboxylate

4-(3-methoxyphenyl) piperazine hydrochloride

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

3-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-thieno[3,2-d]pyrimidine-2,4-dione

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