(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Base Information

Chemical Name:(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide
CAS No.:1401791-48-7
Molecular Formula:C₂₉H₃₁ClN₄O₂S
Molecular Weight:535.11
Hs Code.:

Synonyms:(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

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Chemical Property of (2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

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Technology Process of (2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

There total 8 articles about (2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1429642-78-3
1-(4-(2-morpholinoethyl)phenyl)-1H-benzimidazole-2-thiol

: 1429642-80-7
(R)-2-bromo-N-(2-chloro-4-methylphenyl)propanamide

: 1401791-48-7
(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Guidance literature:: 1-(4-(2-morpholinoethyl)phenyl)-1H-benzimidazole-2-thiol; With potassium carbonate; In methanol; at 45 ℃; for 2h; Sonication;

(R)-2-bromo-N-(2-chloro-4-methylphenyl)propanamide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.3762/bjoc.9.23

Reference yield:

: 1429642-73-8
4-((2-nitrophenyl)amino)phenethyl 4-nitrobenzenesulfonate

: 1401791-48-7
(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2068.65 Torr

3.1: dichloromethane / 1.5 h / 0 - 20 °C

4.1: potassium carbonate / methanol / 2 h / 45 °C / Sonication

4.2: 1 h / 0 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.9.23

Reference yield:

: 2-[4-(2-nitroanilino)phenyl]ethanol

: 1401791-48-7
(2S)-N-(2-chloro-4-methylphenyl)-2-((1-(4-(2-morpholinoethyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 - 60 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2068.65 Torr

4.1: dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium carbonate / methanol / 2 h / 45 °C / Sonication

5.2: 1 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.9.23