(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Base Information

Chemical Name:(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one
CAS No.:1228934-38-0
Molecular Formula:C₃₉H₃₈N₈O₂
Molecular Weight:650.783
Hs Code.:

(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Synonyms:(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

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Chemical Property of (4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

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Technology Process of (4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

There total 6 articles about (4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 2,4-dimethyl-6-piperidin-2-yl-methylpyridine

: 1228935-07-6
[(4S)-4-(1H-indazol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]acetic acid

: 1228934-38-0
(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

: 526183-28-8
2,4-dimethyl-6-piperidin-2-ylmethylpyridine

: 1228935-07-6
[(4S)-4-(1H-indazol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]acetic acid

: 1228934-38-0
(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃;

Reference yield:

: 1228935-06-5
[4-(1H-indazol-3-yl-methyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]acetic acid

: 1228934-38-0
(4S)-6-(2-{2-[(4.6-dimethylpyridin-2-yl)methyl]piperidin-1-yl}-2-oxoethyl)-4-(1H-indazol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine; trifluoroacetic acid / methanol; ethanol; n-heptane; dichloromethane / Resolution of racemate

2: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; trifluoroacetic acid; In methanol; ethanol; n-heptane; dichloromethane;