(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

Base Information

Chemical Name:(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol
CAS No.:871345-91-4
Molecular Formula:C₃₆H₄₄O₆Si
Molecular Weight:600.827
Hs Code.:

Synonyms:(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

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Chemical Property of (1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

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Technology Process of (1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

There total 3 articles about (1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 871345-83-4
(2R,3R)-2,3-Bis-(4-methoxy-benzyloxy)-butane-1,4-diol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 871345-91-4
(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ol052322j

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 871345-91-4
(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / NaH; 18-crown-6 / tetrabutylammonium iodide / tetrahydrofuran / 0 - 20 °C

2: 89 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 82 percent / NaH / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; sodium hydride; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran;
DOI:10.1021/ol052322j

Reference yield:

: 871345-82-3
(2S,3S)-2,3-Bis-(4-methoxy-benzyloxy)-succinic acid diisopropyl ester

: 871345-91-4
(1R,1R)-4-[(tert-butyl-diphenylsilyl)-oxy]-2,3-bis-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

2: 82 percent / NaH / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ol052322j