α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone

Base Information

• Chemical Name: α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone
• CAS No.: 552849-88-4
• Molecular Formula: C₁₀H₇BrFN₃O
• Molecular Weight: 284.087
• Mol file: 552849-88-4.mol

Synonyms:α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone

Chemical Property of α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone

There total 1 articles about α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone (58905-21-8) → α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone (552849-88-4)

Guidance literature:

With bromine; sodium acetate; acetic acid;

DOI:10.1080/10426500307939

Reference yield: 77.8%

S-carboxymethyl O,O-diethyl phosphorodithioate (20819-59-4) + α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone (552849-88-4) → (diethoxy-thiophosphorylsulfanyl)-acetic acid 2-(4-fluoro-phenyl)-2-oxo-1-[1,2,4]triazol-1-yl-ethyl ester

Guidance literature:

With triethylamine; In acetone; at 0 - 5 ℃; for 2h;

DOI:10.1080/10426500307939

Reference yield: 61.3%

(Dipropoxy-thiophosphorylsulfanyl)-acetic acid (31224-81-4) + α-(1H-1,2,4-triazolo-1-yl)-α-bromo-para-fluoroacetophenone (552849-88-4) → (dipropoxy-thiophosphorylsulfanyl)-acetic acid 2-(4-fluoro-phenyl)-2-oxo-1-[1,2,4]triazol-1-yl-ethyl ester

Guidance literature:

With triethylamine; In acetone; at 0 - 5 ℃;

DOI:10.1080/10426500307939

upstream raw materials:

4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone