2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile

Base Information

• Chemical Name: 2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile
• CAS No.: 1162684-49-2
• Molecular Formula: C₂₂H₁₂ClN₃O
• Molecular Weight: 369.81
• Mol file: 1162684-49-2.mol

Synonyms:2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile

Chemical Property of 2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile

There total 1 articles about 2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-amino-4-((4-(4-cyanophenoxy)-3-chlorophenyl)ethynyl)benzonitrile (1162684-36-7) → 2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile (1162684-49-2)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver perchlorate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere; Darkness;

DOI:10.3987/COM-08-S(D)8

Reference yield: 77.0%

2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile (1162684-49-2) + ethylenediamine (107-15-3,85404-18-8) → 6-(4,5-dihydro-1H-imidazol-2-yl)-2-{4-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]-3-chlorophenyl}-1H-indole (1162684-87-8)

Guidance literature:

With sulfur; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.3987/COM-08-S(D)8

Reference yield: 46.0%

2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile (1162684-49-2) → 2-(4-(4-carbamimidoylphenoxy)-3-chlorophenyl)-1H-indole-6-carboximidamide dihydrochloride

Guidance literature:

2-(4-(4-cyanophenyl)-3-chlorophenyl)-1H-indole-6-carbonitrile; With hydrogenchloride; In ethanol; chloroform; at 20 ℃; for 20h;

With ammonia; In ethanol; at 20 ℃; for 48h;

In diethyl ether; ethanol; for 0.5h;

DOI:10.3987/COM-08-S(D)8

upstream raw materials:

3-amino-4-((4-(4-cyanophenoxy)-3-chlorophenyl)ethynyl)benzonitrile

Downstream raw materials:

6-(4,5-dihydro-1H-imidazol-2-yl)-2-{4-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]-3-chlorophenyl}-1H-indole