4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline

Base Information

• Chemical Name: 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline
• CAS No.: 128830-76-2
• Molecular Formula: C₂₄H₁₈ClF₂N₃O
• Molecular Weight: 437.876
• Mol file: 128830-76-2.mol

Synonyms:4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline

Chemical Property of 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline

There total 7 articles about 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

2,4-diflurophenylisocyanate (59025-55-7) + 3-amino-4-(2-chlorophenyl)-6,8-dimethylquinoline (128831-37-8) → 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline (128830-76-2)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00039a020

Reference yield: 61.4%

→ 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline (128830-76-2)

Guidance literature:

Reference yield:

4-(2-chlorophenyl)-6,8-dimethyl-3-quinolinecarboxylic acid (128831-34-5) → 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline (128830-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: DPPA, Et₃N / benzene / Heating

2: benzene / Heating

With diphenyl-phosphinic acid; triethylamine; In benzene;

DOI:10.1021/jm00039a020

upstream raw materials:

2,4-difluorophenylamine

4-(2-Chloro-phenyl)-3-isocyanato-6,8-dimethyl-quinoline

2,4-diflurophenylisocyanate

3-amino-4-(2-chlorophenyl)-6,8-dimethylquinoline

Downstream raw materials:

4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline 1-oxide