(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester
CAS No.:360556-27-0
Molecular Formula:C₁₇H₂₆N₂O₅
Molecular Weight:338.404
Hs Code.:

Synonyms:(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

There total 5 articles about (S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179678-70-7
(S)-2-[(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethyl)-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

: 360556-27-0
(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; water;
DOI:10.1016/0040-4039(95)00214-W

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 360556-27-0
(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / acetonitrile / 20 - 60 °C

2: 101.5 g / DIPEA / acetonitrile / 24 h / 70 °C

3: 93.7 percent / TFA / CH₂Cl₂ / 70 h / 20 °C

4: TEA; DCC / CH₂Cl₂ / 20 h / 20 °C

5: hydroxylamine / ethanol; tetrahydrofuran / 3 h / 20 °C / pH 6.0

With TEA; hydroxylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo015665d

Reference yield:

: 179678-66-1
N-(1-tert-butoxy-acet-2-yl)-(S)-leucine methyl ester

: 360556-27-0
(S)-2-[Hydroxycarbamoylmethyl-(4-methoxy-benzyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 101.5 g / DIPEA / acetonitrile / 24 h / 70 °C

2: 93.7 percent / TFA / CH₂Cl₂ / 70 h / 20 °C

3: TEA; DCC / CH₂Cl₂ / 20 h / 20 °C

4: hydroxylamine / ethanol; tetrahydrofuran / 3 h / 20 °C / pH 6.0

With TEA; hydroxylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo015665d