1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione
• CAS No.: 890658-67-0
• Molecular Formula: C₃₁H₂₇N₅O₅
• Molecular Weight: 549.586

Synonyms:1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione

There total 1 articles about 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanesufonic acid 5-(5-ethynyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-3-yl ester (890658-57-8) → 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione (890658-67-0)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 16h; Heating;

DOI:10.1016/j.tet.2008.02.079

Reference yield: 74.0%

1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione (890658-67-0) → 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-iodoethynyl-1H-pyrimidine-2,4-dione (1030021-60-3)

Guidance literature:

With iodonium di-syn-collidine perchlorate; Ag(coll)2ClO₄; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tet.2008.02.079

Reference yield: 72.0%

1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-ethynyl-1H-pyrimidine-2,4-dione (890658-67-0) → 1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-(1-bromo-2-iodo-vinyl)-1H-pyrimidine-2,4-dione (1030021-57-8)

Guidance literature:

With iodine(I) bromide; In acetonitrile; at 0 ℃;

DOI:10.1016/j.tet.2008.02.079

upstream raw materials:

methanesufonic acid 5-(5-ethynyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-3-yl ester

Downstream raw materials:

1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-(1,2-diiodo-vinyl)-1H-pyrimidine-2,4-dione

1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-(1-bromo-2-iodo-vinyl)-1H-pyrimidine-2,4-dione

1-{4-azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-5-iodoethynyl-1H-pyrimidine-2,4-dione

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