(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Base Information

Chemical Name:(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile
CAS No.:1425794-12-2
Molecular Formula:C₁₉H₁₈FNOSe
Molecular Weight:374.316
Hs Code.:

Synonyms:(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

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Chemical Property of (S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Chemical Property:

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Technology Process of (S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

There total 5 articles about (S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 817203-55-7
(S)-1-(3-chloropropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

: 7101-31-7
dimethyl diselenide

: 1425794-12-2
(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: dimethyl diselenide; With sodium tetrahydroborate; ethanol; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-1-(3-chloropropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 128196-01-0
escitalopram

: 1425794-12-2
(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5 h / Reflux

2.1: methanol / Reflux

2.2: 20 °C

3.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; In tetrahydrofuran; methanol;

Reference yield:

: 1425794-07-5
C₂₂H₂₂ClFN₂O₃

: 1425794-12-2
(S)-1-(4-fluorophenyl)-1-(3-(methyselanyl)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / Reflux

1.2: 20 °C

2.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; In tetrahydrofuran; methanol;