C₂₆H₁₉FN₂O₄S

Base Information

• Chemical Name: C₂₆H₁₉FN₂O₄S
• CAS No.: 1367127-27-2
• Molecular Formula: C₂₆H₁₉FN₂O₄S
• Molecular Weight: 474.512
• Mol file: 1367127-27-2.mol

Synonyms:C₂₆H₁₉FN₂O₄S

Chemical Property of C₂₆H₁₉FN₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₂₆H₁₉FN₂O₄S

There total 8 articles about C₂₆H₁₉FN₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H13FN2O2 (1367127-25-0) + p-toluenesulfonyl chloride (98-59-9) → C26H19FN2O4S (1367127-27-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → C26H19FN2O4S (1367127-27-2)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 100 °C

3: N,N-Dimethylcarbamoyl chloride / dichloromethane / 12 h / 20 °C

4: sodium tetrahydroborate; methanol / 0 °C

5: triethylamine / dichloromethane / 6 h / 20 °C

With methanol; sodium tetrahydroborate; dimethylaminoacetic acid; potassium carbonate; caesium carbonate; triethylamine; N,N-Dimethylcarbamoyl chloride; tri tert-butylphosphoniumtetrafluoroborate; copper(l) iodide; palladium diacetate; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

4-Fluorophenol (371-41-5) → C26H19FN2O4S (1367127-27-2)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 100 °C

3: N,N-Dimethylcarbamoyl chloride / dichloromethane / 12 h / 20 °C

4: sodium tetrahydroborate; methanol / 0 °C

5: triethylamine / dichloromethane / 6 h / 20 °C

With methanol; sodium tetrahydroborate; dimethylaminoacetic acid; potassium carbonate; caesium carbonate; triethylamine; N,N-Dimethylcarbamoyl chloride; tri tert-butylphosphoniumtetrafluoroborate; copper(l) iodide; palladium diacetate; In 1,4-dioxane; dichloromethane; toluene;

upstream raw materials:

1-Bromo-4-fluorobenzene

4-Fluorophenol

C₁₉H₁₃FN₂O₂

p-toluenesulfonyl chloride

Downstream raw materials:

C₂₈H₂₉FN₄O₃

C₂₈H₃₁FN₄O₄

C₂₉H₃₃FN₄O₄