7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_.

Base Information

• Chemical Name: 7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_.
• CAS No.: 114915-24-1
• Molecular Formula: C₄₃H₄₅Cl₃O₁₄
• Molecular Weight: 892.181
• Mol file: 114915-24-1.mol

Synonyms:7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_.

Chemical Property of 7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_.

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_.

There total 1 articles about 7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III_. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-3-phenylacrylic acid (140-10-3) + 7-(2,2,2-trichloroethyloxycarbonyl)baccatin III (103150-33-0) → 7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III. (114915-24-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; at 70 ℃; for 15h;

DOI:10.1016/S0040-4020(01)81313-2

Reference yield:

7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III. (114915-24-1) → taxol (33069-62-4)

Guidance literature:

Multi-step reaction with 4 steps

1: AgNO₃, OsO₄, / acetonitrile; 2-methyl-propan-2-ol / 24 h / Ambient temperature

2: ISi(CH₃)3 / acetonitrile / 0.5 h / 0 °C

3: pyridine / 3 h / Ambient temperature

4: Zn, AcOH, / methanol / 2 h / 60 °C

With osmium(VIII) oxide; trimethylsilyl iodide; silver nitrate; acetic acid; zinc; In pyridine; methanol; acetonitrile; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)81313-2

Reference yield:

7(2,2,2-trichloroethyloxycarbonyl)-13-cinnamoyl baccatin III. (114915-24-1) → 10-acetyldocetaxel (125354-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: AgNO₃, OsO₄, / acetonitrile; 2-methyl-propan-2-ol / 24 h / Ambient temperature

2: 86 percent / Zn, AcOH, / methanol / 2 h / 60 °C

With osmium(VIII) oxide; silver nitrate; acetic acid; zinc; In methanol; acetonitrile; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)81313-2

upstream raw materials:

(E)-3-phenylacrylic acid

7-(2,2,2-trichloroethyloxycarbonyl)baccatin III

Downstream raw materials:

C₄₃H₄₇Cl₃O₁₆

C₄₈H₅₆Cl₃NO₁₇

C₄₈H₅₆Cl₃NO₁₇

C₄₈H₅₆Cl₃NO₁₇