3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

Base Information

Chemical Name:3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid
CAS No.:1346672-45-4
Molecular Formula:C₁₇H₁₄BrNO₂S
Molecular Weight:376.274
Hs Code.:

Synonyms:3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

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Chemical Property of 3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

Chemical Property:

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Technology Process of 3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

There total 3 articles about 3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₆BrNO₂S

: 1346672-45-4
3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

Guidance literature:: C₁₈H₁₆BrNO₂S; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 14h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 3133-81-1
3-methylbenzo[b]thiophene-2-carboxylic acid methyl ester

: 1346672-45-4
3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / benzene / 2 h / Inert atmosphere; Reflux

2.1: caesium carbonate / acetonitrile / 14 h / 50 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 14 h / 20 °C

3.2: pH 5

With N-Bromosuccinimide; lithium hydroxide monohydrate; water; caesium carbonate; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; acetonitrile; benzene;

Reference yield:

: 3-bromomethyl-benzo[b]thiophene-2-carboxylic acid methyl ester

: 1346672-45-4
3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / acetonitrile / 14 h / 50 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 14 h / 20 °C

2.2: pH 5

With lithium hydroxide monohydrate; water; caesium carbonate; In tetrahydrofuran; methanol; acetonitrile;