tert-butyl 4-(methylthio)benzylidenecarbamate

Base Information

• Chemical Name: tert-butyl 4-(methylthio)benzylidenecarbamate
• CAS No.: 1026061-36-8
• Molecular Formula: C₁₃H₁₇NO₂S
• Molecular Weight: 251.349
• Mol file: 1026061-36-8.mol

Synonyms:tert-butyl 4-(methylthio)benzylidenecarbamate

Chemical Property of tert-butyl 4-(methylthio)benzylidenecarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 4-(methylthio)benzylidenecarbamate

There total 2 articles about tert-butyl 4-(methylthio)benzylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H23NO4S2 → tert-butyl 4-(methylthio)benzylidenecarbamate (1026061-36-8)

Guidance literature:

With potassium carbonate; sodium sulfate; In tetrahydrofuran;

DOI:10.1039/b808393b

Reference yield:

4-(Methylthio)benzaldehyde (3446-89-7) → tert-butyl 4-(methylthio)benzylidenecarbamate (1026061-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / methanol; water / 16 h / 20 °C

2: potassium carbonate / dichloromethane / 6 h

With formic acid; potassium carbonate; In methanol; dichloromethane; water;

DOI:10.1021/acs.orglett.7b03609

Reference yield: 88.0%

(E)-1-(3,5-diphenyl-1H-pyrazol-1-yl)but-2-en-1-one + tert-butyl 4-(methylthio)benzylidenecarbamate (1026061-36-8) → C32H33N3O3S

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; 5,5′-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4′-bi-1,3-benzodioxole; In tetrahydrofuran; at -20 ℃; for 24h; enantioselective reaction; Schlenk technique;

DOI:10.1002/cjoc.202000432

upstream raw materials:

4-(Methylthio)benzaldehyde

Downstream raw materials:

tert-butyl (1R,2S)-2-(bis(2,4-dimethylpentan-3-yloxy)phosphoryl)-1-(4-(methylthio)phenyl)-2-nitropropylcarbamate