(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Base Information

Chemical Name:(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile
CAS No.:956406-81-8
Molecular Formula:C₁₁H₉Cl₂NO
Molecular Weight:242.105
Hs Code.:

Synonyms:(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Chemical Property:

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Technology Process of (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

There total 2 articles about (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 956406-81-8
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Guidance literature:: 3,4-dichloro-benzeneacetonitrile; With sodium amide; In tetrahydrofuran; at -25 - 20 ℃; for 2h;

(R)-(-)-epichlorohydrin; With sodium amide; In tetrahydrofuran; at -25 - 20 ℃; for 8h;

Reference yield:

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 956406-85-2
(1R,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

: 956406-81-8
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Guidance literature:: 3,4-dichloro-benzeneacetonitrile; With sodium amide; In tetrahydrofuran; at -25 - 20 ℃; for 2h;

(R)-(-)-epichlorohydrin; With sodium amide; In tetrahydrofuran; at -25 - 15 ℃; for 8h;

With ammonium chloride; In tetrahydrofuran; water; ethyl acetate; Product distribution / selectivity;

Reference yield: 45.0%

: 956406-81-8
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

: 956406-82-9
((1R,2S)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl)methanol

Guidance literature:: (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

With Glauber's salt; In tetrahydrofuran; at 10 ℃; for 16h;