N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

Base Information

Chemical Name:N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde
CAS No.:727726-86-5
Molecular Formula:C₂₁H₂₃NO₅
Molecular Weight:369.417
Hs Code.:

Synonyms:N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

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Chemical Property of N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

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Technology Process of N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

There total 6 articles about N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 727726-91-2
N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetic acid ethyl ester

: 727726-86-5
N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1.33333h;
DOI:10.1515/znb-2004-0415

Reference yield:

: 3600-86-0
2,5-dimethoxyphenethylamine

: 727726-86-5
N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / aq. K₂CO₃ / diethyl ether / 1.5 h / 0 °C

2: 59 percent / P₄O₁₀ / toluene / 1 h / Heating

3: 98 percent / H₂; AcOH / Pd/C / ethanol / 1.17 h / 25 °C / 3075.25 Torr

4: 67 percent / Et₃N / CH₂Cl₂ / 3 h / 25 °C

5: 70 percent / DIBAL / toluene / 1.33 h / -78 °C

With phosphorus pentoxide; hydrogen; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; toluene; 2: Bischler-Napieralski reaction;
DOI:10.1515/znb-2004-0415

Reference yield:

: 727726-89-8
N-(2-(2,5-dimethoxyphenyl)ethyl)-malonic acid ethyl ester amide

: 727726-86-5
N-carbobenzyloxy-(5,8-dimethoxy-3,4-dihydro-2H-isoquinolin-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / P₄O₁₀ / toluene / 1 h / Heating

2: 98 percent / H₂; AcOH / Pd/C / ethanol / 1.17 h / 25 °C / 3075.25 Torr

3: 67 percent / Et₃N / CH₂Cl₂ / 3 h / 25 °C

4: 70 percent / DIBAL / toluene / 1.33 h / -78 °C

With phosphorus pentoxide; hydrogen; diisobutylaluminium hydride; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; toluene; 1: Bischler-Napieralski reaction;
DOI:10.1515/znb-2004-0415