3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

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Chemical Name:3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile
CAS No.:1089178-56-2
Molecular Formula:C₂₀H₁₄BrClFN₃O₃
Molecular Weight:478.705
Hs Code.:

Synonyms:3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

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Chemical Property of 3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

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Technology Process of 3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

There total 4 articles about 3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1089178-81-3
C₁₅H₉Br₂ClFNO

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1089178-56-2
3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

Guidance literature:: thymin; With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; at 120 ℃; for 2h;

C₁₅H₉Br₂ClFNO; iodine; In 1,2-dichloro-ethane; at 78 ℃; for 16h;

Reference yield:

: 1007571-94-9
C₁₆H₁₀BrClFNO₃

: 1089178-56-2
3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 80 °C

1.2: 0 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

3.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane / 2 h / 120 °C

3.2: 16 h / 78 °C

With sodium tetrahydroborate; chloro-trimethyl-silane; carbon tetrabromide; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1007572-07-7
[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid

: 1089178-56-2
3-{6-bromo-2-fluoro-3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; dichloromethane / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 80 °C

2.2: 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

4.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane / 2 h / 120 °C

4.2: 16 h / 78 °C

With sodium tetrahydroborate; chloro-trimethyl-silane; carbon tetrabromide; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; methanol; dichloromethane;