(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

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Chemical Name:(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole
CAS No.:868761-91-5
Molecular Formula:C₁₉H₂₀N₄O
Molecular Weight:320.394
Hs Code.:

Synonyms:(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

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Chemical Property of (4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

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Technology Process of (4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

There total 2 articles about (4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4S)-5-Azido-1-phenyl-4-((R)-1-phenyl-ethylamino)-pent-1-yn-3-ol

: 868761-91-5
(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

Guidance literature:: In N,N-dimethyl-formamide; at 130 ℃; for 16h;
DOI:10.1055/s-2005-871974

Reference yield:

: (R)-3-Phenyl-1-[(S)-1-((R)-1-phenyl-ethyl)-aziridin-2-yl]-prop-2-yn-1-ol

: 868761-91-5
(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: azidotrimethylsilane / CH₂Cl₂ / 3 h / 20 °C

2: 106 mg / dimethylformamide / 16 h / 130 °C

With trimethylsilylazide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-871974

Reference yield: 84.0%

: 868761-91-5
(4S,5S)-4-hydroxy-3-phenyl-5-{(1R)-1-phenylethylamino}-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

: 3-phenyl-5-amino-4-hydroxy-5,6-dihydro-4H-pyrrolo[1,2-c][1,2,3]triazole

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; at 20 ℃; for 30h; under 6205.78 Torr;
DOI:10.1055/s-2005-871974