N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide
CAS No.:140395-41-1
Molecular Formula:C₃₂H₅₀N₂O₅SSi
Molecular Weight:602.911
Hs Code.:

Synonyms:N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

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Chemical Property of N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

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Technology Process of N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

There total 12 articles about N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140368-00-9
2-[(S)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-ethanol

: 140395-41-1
N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / bisacodyl / dichloromethane

2: sodium hydrogencarbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

3: acetonitrile / Heating

4: potassium hexamethylsilazane / -78 °C

5: triethylamine / dmap / dichloromethane

6: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

7: dichloromethane / 1 h / 0 °C

8: sodium azide / N,N-dimethyl-formamide / 60 °C

9: toluene / Heating

With sodium azide; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; dmap; bisacodyl; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(91)80195-C

Reference yield:

: 140367-94-8
[(S)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-acetaldehyde

: 140395-41-1
N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: sodium tetrahydroborate / methanol

2: triethylamine / bisacodyl / dichloromethane

3: sodium hydrogencarbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

4: acetonitrile / Heating

5: potassium hexamethylsilazane / -78 °C

6: triethylamine / dmap / dichloromethane

7: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

8: dichloromethane / 1 h / 0 °C

9: sodium azide / N,N-dimethyl-formamide / 60 °C

10: toluene / Heating

With sodium tetrahydroborate; sodium azide; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; dmap; bisacodyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(91)80195-C

Reference yield:

: (S)-4-Hydroxy-2-triisopropylsilanyloxy-butyraldehyde

: 140395-41-1
N-[(S)-1-Hydroxymethyl-3-((S)-3-triisopropylsilanyloxy-4,5-dihydro-3H-pyrrol-2-yl)-propyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hexamethylsilazane / -78 °C

2: triethylamine / dmap / dichloromethane

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

4: dichloromethane / 1 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 60 °C

6: toluene / Heating

With sodium azide; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(91)80195-C