5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621705-18-7
Molecular Formula:C₃₅H₂₈F₂N₄O₄S
Molecular Weight:638.695
Hs Code.:

5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 9 articles about 5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1256359-96-2
4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1621706-27-1
5-(6-chloro-5-(1-(hydroxymethyl)cyclopropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621705-18-7
5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: 4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-(6-chloro-5-(1-(hydroxymethyl)cyclopropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide; With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); caesium carbonate; In 1,4-dioxane; water; at 80 ℃;

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1621706-25-9
1-(6-bromo-2-chloropyridin-3-yl)cyclopropanecarbonitrile

: 1621705-18-7
5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 70 °C

3.1: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 80 °C

3.2: 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); diisobutylaluminium hydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1227599-35-0
(6-bromo-2-chloropyridin-3-yl)methanol

: 1621705-18-7
5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 2 h / 0 °C

2.1: dimethyl sulfoxide / 20 h / 20 °C

3.1: sodium hydroxide; tetrabutylammomium bromide / water / 2 h / 50 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C

4.2: 1 h / 20 °C

5.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 70 °C

6.1: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 80 °C

6.2: 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); tetrabutylammomium bromide; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;