7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

Base Information

Chemical Name:7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one
CAS No.:1352122-60-1
Molecular Formula:C₂₇H₃₁ClN₂O₄
Molecular Weight:483.007
Hs Code.:

Synonyms:7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

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Chemical Property of 7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

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Technology Process of 7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

There total 6 articles about 7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1578300-95-4
7-(4-bromobutoxy)-8-chloro-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

: 1352122-60-1
7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; Reflux;
DOI:10.1016/j.ejmech.2014.01.012

Reference yield:

: 627-93-0
hexanedioic acid dimethyl ester

: 1352122-60-1
7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride; triethylamine / dichloromethane / 0 - 20 °C

2: bismuth (III) nitrate pentahydrate / 80 °C

3: potassium carbonate / acetone / Reflux

4: potassium iodide; potassium carbonate / acetonitrile / Reflux

With aluminum (III) chloride; bismuth (III) nitrate pentahydrate; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile; 1: |Dieckmann Condensation / 2: |Pechmann Condensation;
DOI:10.1016/j.ejmech.2014.01.012

Reference yield:

: 124-04-9
Adipic acid

: 1352122-60-1
7-{4-[4-(2-methoxyphenyl)piperazin-1-yl-butoxy]}-8-chloro-2,3-dihydro-1H-cyclopentene[c]benzopyran-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / Reflux

2: aluminum (III) chloride; triethylamine / dichloromethane / 0 - 20 °C

3: bismuth (III) nitrate pentahydrate / 80 °C

4: potassium carbonate / acetone / Reflux

5: potassium iodide; potassium carbonate / acetonitrile / Reflux

With aluminum (III) chloride; bismuth (III) nitrate pentahydrate; sulfuric acid; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile; 2: |Dieckmann Condensation / 3: |Pechmann Condensation;
DOI:10.1016/j.ejmech.2014.01.012