Technology Process of (2E,4E,6E,8E)-9-(3-Dimethylamino-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenal
There total 14 articles about (2E,4E,6E,8E)-9-(3-Dimethylamino-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-bromosuccinimide / CCl4; hexane / 1 h / Heating
2: 68 percent / sodium carbonate / tetrahydrofuran; H2O / 5 h / Ambient temperature
3: 40 percent / NaH / tetrahydrofuran / 1 h / 25 °C
4: 1.) DIBAL, ethyl acetate; 2.) 5percent aq. silica / 1.) hexane, -78 deg C, 30 min; 2.) -78 deg C, 30 min then 25 deg C, 3 h
5: 55 percent / NaH / tetrahydrofuran / 1 h / 25 °C
6: 1.) 1 M diisobutylaluminum hydride, ethyl acetate; 2.) 5percent aq. silica / 1.) hexane, -78 deg C, 30 min; 2.) -78 deg C then 25 deg C
With
N-Bromosuccinimide; silica gel; sodium hydride; diisobutylaluminium hydride; sodium carbonate; ethyl acetate;
In
tetrahydrofuran; tetrachloromethane; hexane; water;
DOI:10.1021/ja00311a050
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 55 percent / NaH / tetrahydrofuran / 1 h / 25 °C
2: 1.) 1 M diisobutylaluminum hydride, ethyl acetate; 2.) 5percent aq. silica / 1.) hexane, -78 deg C, 30 min; 2.) -78 deg C then 25 deg C
With
silica gel; sodium hydride; diisobutylaluminium hydride; ethyl acetate;
In
tetrahydrofuran;
DOI:10.1021/ja00311a050
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 68 percent / sodium carbonate / tetrahydrofuran; H2O / 5 h / Ambient temperature
2: 40 percent / NaH / tetrahydrofuran / 1 h / 25 °C
3: 1.) DIBAL, ethyl acetate; 2.) 5percent aq. silica / 1.) hexane, -78 deg C, 30 min; 2.) -78 deg C, 30 min then 25 deg C, 3 h
4: 55 percent / NaH / tetrahydrofuran / 1 h / 25 °C
5: 1.) 1 M diisobutylaluminum hydride, ethyl acetate; 2.) 5percent aq. silica / 1.) hexane, -78 deg C, 30 min; 2.) -78 deg C then 25 deg C
With
silica gel; sodium hydride; diisobutylaluminium hydride; sodium carbonate; ethyl acetate;
In
tetrahydrofuran; water;
DOI:10.1021/ja00311a050
