(1R,2S)-2-phenylcyclopropyl phenyl sulfone

Base Information

Chemical Name:(1R,2S)-2-phenylcyclopropyl phenyl sulfone
CAS No.:1233934-50-3
Molecular Formula:C₁₅H₁₄O₂S
Molecular Weight:258.341
Hs Code.:

Synonyms:(1R,2S)-2-phenylcyclopropyl phenyl sulfone

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Chemical Property of (1R,2S)-2-phenylcyclopropyl phenyl sulfone

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Technology Process of (1R,2S)-2-phenylcyclopropyl phenyl sulfone

There total 2 articles about (1R,2S)-2-phenylcyclopropyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 56069-39-7
diethyl phenylsulfonylmethylphosphonate

: 20780-54-5
(S)-styrene oxide

: 1233934-50-3
(1R,2S)-2-phenylcyclopropyl phenyl sulfone

Guidance literature:: diethyl phenylsulfonylmethylphosphonate; With sodium hydride; In 1,2-dimethoxyethane; at 25 ℃;

(S)-styrene oxide; In 1,2-dimethoxyethane; at 140 ℃; optical yield given as %ee; stereospecific reaction;
DOI:10.1021/jo100844g

Reference yield: 73.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1538-96-1
α-diazomethyl phenyl sulfone

: 1233934-50-3
(1R,2S)-2-phenylcyclopropyl phenyl sulfone

Guidance literature:: With C₁₅H₁₂NO^(1-)*4C₂H₃N*Ru⁽²⁺⁾*F₆P^(1-); In dichloromethane; at -10 ℃; for 0.0833333h; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.202006786

Reference yield:

: 1233934-50-3
(1R,2S)-2-phenylcyclopropyl phenyl sulfone

: C₁₅H₁₅NO₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 - 20 °C

2.1: triethylamine / tert-butyl alcohol / 0.5 h / 28 °C / Inert atmosphere; Sealed tube

With n-butyllithium; triethylamine; In 1,2-dimethoxyethane; hexane; tert-butyl alcohol;
DOI:10.1002/anie.202006786