(E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone

Base Information

• Chemical Name: (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone
• CAS No.: 395642-71-4
• Molecular Formula: C₂₂H₃₁NO₄S
• Molecular Weight: 405.558
• Mol file: 395642-71-4.mol

Synonyms:(E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone

Chemical Property of (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone

There total 3 articles about (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[(1S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]propenone (138381-26-7) + 1-bromo-2-(1-methoxyethenyl)cyclohex-1-ene (395642-72-5) → (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone (395642-71-4)

Guidance literature:

With triethylamine; triphenylphosphine; palladium diacetate; In N,N-dimethyl-formamide; at 90 ℃; for 18.5h;

DOI:10.1002/1521-3765(20010917)7:18<4035::AID-CHEM4035>3.0.CO;2-P

Reference yield:

2-bromocyclohexanone (1056477-06-5,822-85-5) → (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone (395642-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi; HMDS / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 62 percent / tetrahydrofuran; hexane / 25.5 h / -78 - 20 °C

2.1: 74 percent / PPh₃; LiCl / Pd(OAc)2 / dimethylformamide / 6.5 h / 60 - 75 °C

3.1: 167 mg / Et₃N; PPh₃ / Pd(OAc)2 / dimethylformamide / 18.5 h / 90 °C

With n-butyllithium; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; palladium diacetate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.1: Stille coupling / 3.1: Heck coupling;

DOI:10.1002/1521-3765(20010917)7:18<4035::AID-CHEM4035>3.0.CO;2-P

Reference yield:

1-bromo-2-trifluoromethanesulfonyloxycyclohexene (213340-08-0) → (E)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-[2-(1-methoxy-vinyl)-cyclohex-1-enyl]-propenone (395642-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / PPh₃; LiCl / Pd(OAc)2 / dimethylformamide / 6.5 h / 60 - 75 °C

2: 167 mg / Et₃N; PPh₃ / Pd(OAc)2 / dimethylformamide / 18.5 h / 90 °C

With triethylamine; triphenylphosphine; lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; 1: Stille coupling / 2: Heck coupling;

DOI:10.1002/1521-3765(20010917)7:18<4035::AID-CHEM4035>3.0.CO;2-P

upstream raw materials:

1-[(1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]propenone

1-bromo-2-(1-methoxyethenyl)cyclohex-1-ene

2-bromocyclohexanone

1-bromo-2-trifluoromethanesulfonyloxycyclohexene

Downstream raw materials:

(E)-3-(2-acetyl-cyclohex-1-enyl)-1-((1S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-propenone