1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:1344029-42-0
Molecular Formula:C₂₆H₃₄N₂O*ClH
Molecular Weight:427.03
Hs Code.:

Synonyms:1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Chemical Property of 1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

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Technology Process of 1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 5 articles about 1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1344029-13-5
4-[(1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine

: 122-78-1
phenylacetaldehyde

: 1344029-42-0
1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: 4-[(1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine; phenylacetaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

With hydrogenchloride; In ethyl acetate;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1344029-05-5
C₁₂H₁₇N*ClH

: 1344029-42-0
1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1327056-67-6
C₂₃H₃₄N₂O₃

: 1344029-42-0
1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.59.1029