methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Base Information

• Chemical Name: methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate
• CAS No.: 1428533-34-9
• Molecular Formula: C₁₉H₂₃ClN₄O₄
• Molecular Weight: 406.869
• Mol file: 1428533-34-9.mol

Synonyms:methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Chemical Property of methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate

There total 2 articles about methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,1-dimethylethylurea (1118-12-3) + 2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1178896-02-0,1251932-92-9) → methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate (1428533-34-9)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; at 110 ℃; for 0.333333h; chemoselective reaction; Microwave irradiation;

DOI:10.1021/jm301887f

Reference yield:

C12H14N2O2 (1247083-62-0) → methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate (1428533-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / diethyl ether / 0.08 h

1.2: Reflux

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.33 h / 110 °C / Microwave irradiation

With hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; diethyl ether;

DOI:10.1021/jm301887f

Reference yield:

methyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetate (1428533-34-9) → C18H21ClN4O4

Guidance literature:

With water; potassium carbonate; In acetonitrile; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jm301887f

upstream raw materials:

1,1-dimethylethylurea

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

C₁₂H₁₄N₂O₂

Downstream raw materials:

2-(2-(3-(3-(tert-butyl)ureido)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide