C₁₉H₁₈ClN₃O₂

Base Information

Chemical Name:C₁₉H₁₈ClN₃O₂
CAS No.:1192603-44-3
Molecular Formula:C₁₉H₁₈ClN₃O₂
Molecular Weight:355.824
Hs Code.:

C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₉H₁₈ClN₃O₂

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Chemical Property of C₁₉H₁₈ClN₃O₂

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Technology Process of C₁₉H₁₈ClN₃O₂

There total 6 articles about C₁₉H₁₈ClN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1192603-42-1
4-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]benzoic acid

: 1192603-44-3
C₁₉H₁₈ClN₃O₂

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 151004-19-2
(4S,5S)-5-methyl-4-hydroxy-2-oxopyrrolidine

: 1192603-44-3
C₁₉H₁₈ClN₃O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium bis(2-methoxyethoxy)aluminum dihydride / toluene; tetrahydrofuran / 3 h / 5 - 70 °C

1.2: 16 h / 20 °C

1.3: 1 h / 100 °C

2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: 16.5 h / -78 - 20 °C / Inert atmosphere

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 4 h / 70 °C

5.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 3.5 h / 20 - 50 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / N,N-dimethyl-formamide / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; N-hydroxybenzotriazole ammonium salt; lithium hydroxide monohydrate; sodium bis(2-methoxyethoxy)aluminum dihydride; palladium diacetate; sulfur trioxide pyridine complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 1192608-22-2
2-chloro-4-[(2S)-2-methyl-3-oxopyrrolidin-1-yl]benzonitrile

: 1192603-44-3
C₁₉H₁₈ClN₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 16.5 h / -78 - 20 °C / Inert atmosphere

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 4 h / 70 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 3.5 h / 20 - 50 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / N,N-dimethyl-formamide / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; N-hydroxybenzotriazole ammonium salt; lithium hydroxide monohydrate; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.001