5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-

Base Information

Chemical Name:5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-
CAS No.:114685-14-2
Molecular Formula:C₁₇H₁₈N₄O
Molecular Weight:294.356
Hs Code.:
DSSTox Substance ID:DTXSID10150828
Wikidata:Q83017032
Pharos Ligand ID:A5B44AU6YST5
ChEMBL ID:CHEMBL137404

Synonyms:BRN 5596867;CHEMBL137404;114685-14-2;5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-;2-Methyl-4-(4-morpholinyl)-6-phenyl-5H-pyrrolo(3,2-d)pyrimidine;4-(2-Methyl-6-phenylpyrrolo[2,3-e]pyrimidin-4-yl)morpholine;SCHEMBL5773978;SCHEMBL5773980;DTXSID10150828;WYCIFGJZKFGXHZ-UHFFFAOYSA-N;BDBM50093639;LS-139594;2-Methyl-4-morpholin-4-yl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

Suppliers and Price of 5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-

Chemical Property:

Vapor Pressure:3.97E-09mmHg at 25°C
Boiling Point:473.3°Cat760mmHg
Flash Point:240.1°C
Density:1.262g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:294.14806121
Heavy Atom Count:22
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(C(=N1)N3CCOCC3)NC(=C2)C4=CC=CC=C4

Technology Process of 5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl-

There total 5 articles about 5H-Pyrrolo(3,2-d)pyrimidine, 2-methyl-4-(4-morpholinyl)-6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

: 110-91-8,99108-56-2
morpholine

: 2-Methyl-4-chloro-6-phenylpyrrolo<3,2-d>pyrimidine hydrochloride

: 114685-14-2
4-(2-methyl-6-phenylpyrrolo[2,3-e]pyrimidin-4-yl)morpholine

Guidance literature:: With potassium carbonate; In water; for 4h;
DOI:10.1007/BF00758443

Reference yield:

: 95980-17-9
2-methyl-6-phenylpyrrolo[3,2-d]pyrimidin-4-ol

: 114685-14-2
4-(2-methyl-6-phenylpyrrolo[2,3-e]pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / POCl₃; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating

2: 33 percent / K₂CO₃ / H₂O / 4 h / 120 °C

With potassium carbonate; N,N-diethylaniline; trichlorophosphate; In water; 1,2-dichloro-ethane;
DOI:10.1021/jm000269t

Reference yield:

: 61151-90-4
2-benzoylamino-3-oxobutyric acid ethyl ester

: 114685-14-2
4-(2-methyl-6-phenylpyrrolo[2,3-e]pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOEt / ethanol / 0.5 h / 20 °C

1.2: 44 percent / ethanol / 20 °C

2.1: 15 percent / NaOEt / 0.33 h / 360 °C

3.1: 44 percent / POCl₃; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating

4.1: 33 percent / K₂CO₃ / H₂O / 4 h / 120 °C

With sodium ethanolate; potassium carbonate; N,N-diethylaniline; trichlorophosphate; In ethanol; water; 1,2-dichloro-ethane; 2.1: Madelung cyclization;
DOI:10.1021/jm000269t