N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

Base Information

Chemical Name:N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide
CAS No.:902453-35-4
Molecular Formula:C₂₂H₂₀BrF₃NOP
Molecular Weight:482.28
Hs Code.:

Synonyms:N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

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Chemical Property of N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

Chemical Property:

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Technology Process of N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

There total 3 articles about N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 902453-28-5
N-[1-(4-bromophenyl)-1-ethoxy-2,2,2-trifluoroethyl]-P,P-diphenylphosphinic amide

: 557-20-0
diethylzinc

: N-[(1S)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

: 902453-35-4
N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); (2R,5R)-1-{2-[(2R,5R)-2,5-dimethylphospholan-1-yl]phenyl}-2,5-dimethylphospholane 1-oxide; In toluene; at 0 ℃; for 16h; Title compound not separated from byproducts;
DOI:10.1021/ol0607847

Reference yield:

: 5994-87-6
diphenylphosphinamide

: 902453-35-4
N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / CH₂Cl₂ / 96 h / 20 °C

2: copper(II) trifluoromethanesulfonate; (R,R)-MeDuPHOS monoxide / toluene / 16 h / 0 °C

With copper(II) bis(trifluoromethanesulfonate); (2R,5R)-1-{2-[(2R,5R)-2,5-dimethylphospholan-1-yl]phenyl}-2,5-dimethylphospholane 1-oxide; In dichloromethane; toluene;
DOI:10.1021/ol0607847

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 902453-35-4
N-[(1R)-1-(4-bromophenyl)-1-(trifluoromethyl)propyl]-P,P-diphenylphosphinic amide

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / CH₂Cl₂ / 96 h / 20 °C

2: copper(II) trifluoromethanesulfonate; (R,R)-MeDuPHOS monoxide / toluene / 16 h / 0 °C

With copper(II) bis(trifluoromethanesulfonate); (2R,5R)-1-{2-[(2R,5R)-2,5-dimethylphospholan-1-yl]phenyl}-2,5-dimethylphospholane 1-oxide; In dichloromethane; toluene;
DOI:10.1021/ol0607847