(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

Base Information

Chemical Name:(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate
CAS No.:1373552-18-1
Molecular Formula:C₁₇H₁₈ClN₃O₃
Molecular Weight:347.801
Hs Code.:

Synonyms:(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

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Chemical Property of (E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

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Technology Process of (E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

There total 4 articles about (E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1373552-14-7
(E)-methyl-2-(((6-chloro-5-formylpyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

: 1373552-18-1
(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In ethanol; at 20 ℃;
DOI:10.1055/s-0031-1290333

Reference yield:

: 1021167-64-5
(E)-methyl-2-((methylamino)methyl)-3-phenylacrylate

: 1373552-18-1
(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / chloroform / 0.5 h / 0 - 5 °C

2: sodium cyanoborohydride; acetic acid / ethanol / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In ethanol; chloroform;
DOI:10.1055/s-0031-1290333

Reference yield:

: 124957-36-4
Methyl 3-acetoxy-2-methylene-3-phenylpropanoate

: 1373552-18-1
(E)-methyl 2-(((6-chloro-5-(hydroxymethyl)pyrimidin-4-yl)(methyl)amino)methyl)-3-phenylacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; ethanol / 0.5 h / 0 °C

2: triethylamine / chloroform / 0.5 h / 0 - 5 °C

3: sodium cyanoborohydride; acetic acid / ethanol / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1055/s-0031-1290333