methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

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Chemical Name:methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate
CAS No.:1268619-73-3
Molecular Formula:C₂₃H₂₀N₄O₄
Molecular Weight:416.436
Hs Code.:

Synonyms:methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

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Chemical Property of methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

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Technology Process of methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

There total 9 articles about methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 4412-96-8
3-methylfuran-2-carboxylic acid

: 1268619-71-1
methyl 5-(4-((3-aminophenyl)amino)pyridin-2-yl)-1H-pyrrole-3-carboxylate

: 1268619-73-3
methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

Guidance literature:: 3-methylfuran-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

methyl 5-(4-((3-aminophenyl)amino)pyridin-2-yl)-1H-pyrrole-3-carboxylate; In water; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 99-09-2
3-nitro-aniline

: 1268619-73-3
methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene. / palladium diacetate / toluene / 18 h / 90 °C / Sealed tube

2.1: triethylamine / dmap / tetrahydrofuran / 18 h / 20 °C

3.1: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 105 °C / Sealed vessel

4.1: silica gel / toluene / 20 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 3 h / 20 °C

With 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene.; hydrogen; silica gel; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dmap; palladium 10% on activated carbon; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 153034-86-7
2-chloro-4-iodopyridine

: 1268619-73-3
methyl 5-[4-({3-[(3-methyl-2-furoyl)amino]phenyl}amino)pyridin-2-yl]-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene. / palladium diacetate / toluene / 18 h / 90 °C / Sealed tube

2.1: triethylamine / dmap / tetrahydrofuran / 18 h / 20 °C

3.1: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 105 °C / Sealed vessel

4.1: silica gel / toluene / 20 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 3 h / 20 °C

With 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene.; hydrogen; silica gel; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dmap; palladium 10% on activated carbon; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;