(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Name:(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1186606-54-1
Molecular Formula:C₂₇H₃₆N₄O₆
Molecular Weight:512.606
Hs Code.:

Synonyms:(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of (S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of (S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

There total 5 articles about (S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₈N₄O₇

: 1186606-54-1
(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

: 204378-41-6
methyl 6-chloro-4-methoxypicolinate

: 1186606-54-1
(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere

2.1: lithium hydroxide / methanol; water / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: 1,4-dioxane / 2 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1.1: |Negishi Coupling;
DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

: pentan-3-yl 4-methoxy-6-(pentan-3-yl)picolinate

: 1186606-54-1
(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / methanol; water / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: 1,4-dioxane / 2 h / 100 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.03.020