Technology Process of Boc-Val-Glu(OBzl)P(OPh)2
There total 8 articles about Boc-Val-Glu(OBzl)P(OPh)2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
acetonitrile;
at 20 ℃;
for 12h;
DOI:10.1016/j.bmcl.2012.12.074
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; hydrogen bromide / 2 h / 20 °C
2.1: dichloromethane / 24 h / 20 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 3 h / Inert atmosphere
4.1: hydrogenchloride / diethyl ether / 24 h / 20 °C
5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 12 h / 20 °C
With
hydrogenchloride; hydrogen bromide; potassium hexamethylsilazane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.074
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 24 h / 20 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 3 h / Inert atmosphere
3.1: hydrogenchloride / diethyl ether / 24 h / 20 °C
4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 12 h / 20 °C
With
hydrogenchloride; potassium hexamethylsilazane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.074
