2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

Base Information

Chemical Name:2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester
CAS No.:909554-64-9
Molecular Formula:C₃₆H₅₆O₉
Molecular Weight:632.835
Hs Code.:

2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

Synonyms:2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

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Chemical Property of 2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

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Technology Process of 2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

There total 28 articles about 2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 909554-51-4
2-Methyl-2-[(2R,6S)-6-(2-oxo-propyl)-tetrahydro-pyran-2-yl]-propionic acid ethyl ester

: 909554-63-8
2-Methoxy-6-{3-[(2S,6S)-6-((S)-3-methyl-4-oxo-butyl)-tetrahydro-pyran-2-yl]-propyl}-benzoic acid methyl ester

: 909554-64-9
2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In diethyl ether; at -78 ℃; for 5.33333h;
DOI:10.1002/ejoc.200600106

Reference yield:

: 909554-56-9
(6S)-2-acetoxy-6-allyltetrahydropyran

: 909554-64-9
2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TMSOTf / diethyl ether / 24 h / -78 °C

2: 89 percent / CuCl; O₂ / PdCl₂ / H₂O; dimethylformamide / 20 °C

3: 55 percent / Et₃N; Bu₂BOTf / diethyl ether / 5.33 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; di-n-butylboryl trifluoromethanesulfonate; oxygen; triethylamine; copper(l) chloride; palladium dichloride; In diethyl ether; water; N,N-dimethyl-formamide; 2: Wacker oxidation;
DOI:10.1002/ejoc.200600106

Reference yield:

: (S)-7-[1,3]Dioxolan-2-yl-hept-1-en-4-ol

: 909554-64-9
2-[3-((2S,6S)-6-{(3S,4R)-7-[(2S,6R)-6-(1-Ethoxycarbonyl-1-methyl-ethyl)-tetrahydro-pyran-2-yl]-4-hydroxy-3-methyl-6-oxo-heptyl}-tetrahydro-pyran-2-yl)-propyl]-6-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. HCl / tetrahydrofuran / 8 h / 30 °C

2: 73 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

3: TMSOTf / diethyl ether / 24 h / -78 °C

4: 89 percent / CuCl; O₂ / PdCl₂ / H₂O; dimethylformamide / 20 °C

5: 55 percent / Et₃N; Bu₂BOTf / diethyl ether / 5.33 h / -78 °C

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; di-n-butylboryl trifluoromethanesulfonate; oxygen; potassium hexamethylsilazane; triethylamine; copper(l) chloride; palladium dichloride; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; 4: Wacker oxidation;
DOI:10.1002/ejoc.200600106