methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

Base Information

Chemical Name:methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate
CAS No.:144694-28-0
Molecular Formula:C₁₅H₁₆N₆O₅
Molecular Weight:360.329
Hs Code.:

Synonyms:methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

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Chemical Property of methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

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Technology Process of methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

There total 6 articles about methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 144694-27-9
[4-Amino-6-((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethylamino)-5-nitro-pyrimidin-2-yl]-carbamic acid methyl ester

: 144694-28-0
methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00104a005

Reference yield:

: 144694-22-4
methyl <4-azido-6-chloropyrimidin-2-yl>carbamate

: 144694-28-0
methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / Raney Ni / ethanol / 3 h / 760 Torr / Ambient temperature

2: 51 percent / fuming HNO₃, conc. H₂SO₄ / 1 h / 30 - 35 °C

3: 81 percent / Et₃N / tetrahydrofuran / 21 h / Ambient temperature

4: 90 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; chromium(VI) oxide; sulfuric acid; hydrogen; nitric acid; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00104a005

Reference yield:

: 65004-51-5
(4,6-dichloro-pyrimidin-2-yl)-carbamic acid methyl ester

: 144694-28-0
methyl <(S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitropyrimidin-2-yl>carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / aq. NaN₃ / propan-2-ol / 1.5 h / Heating

2: 97 percent / H₂ / Raney Ni / ethanol / 3 h / 760 Torr / Ambient temperature

3: 51 percent / fuming HNO₃, conc. H₂SO₄ / 1 h / 30 - 35 °C

4: 81 percent / Et₃N / tetrahydrofuran / 21 h / Ambient temperature

5: 90 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; chromium(VI) oxide; sodium azide; sulfuric acid; hydrogen; nitric acid; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00104a005