3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

Base Information

Chemical Name:3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid
CAS No.:1292306-14-9
Molecular Formula:C₃₆H₃₉F₆N₃O₇S
Molecular Weight:771.778
Hs Code.:

3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

Synonyms:3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

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Chemical Property of 3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

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Technology Process of 3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

There total 10 articles about 3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292307-35-7
(4-hydroxy-2-(3-hydroxypropyl)-4-(2-methoxyphenyl)piperidin-1-yl)((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidin-3-yI)methanone

: 1292306-14-9
3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

Guidance literature:: With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1292306-14-9
3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 0.5 h / -23 °C

2.1: zinc; acetic acid / 16 h / 50 °C

3.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

4.2: 0.5 h

5.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

6.1: hydrogen / palladium-on-charcoal / ethyl acetate / 2 h

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

9.1: sodium periodate / ruthenium trichloride / tetrachloromethane; acetonitrile; water / 16 h / 20 °C

With sodium periodate; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; zinc; dmap; ruthenium trichloride; palladium-on-charcoal; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1292307-29-9
benzyl 2-allyl-4-oxopiperidine-1-carboxylate

: 1292306-14-9
3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

2.2: 0.5 h

3.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

4.1: hydrogen / palladium-on-charcoal / ethyl acetate / 2 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7.1: sodium periodate / ruthenium trichloride / tetrachloromethane; acetonitrile; water / 16 h / 20 °C

With sodium periodate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; dmap; ruthenium trichloride; palladium-on-charcoal; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile;