Technology Process of 3-(2-chloroethyl)-8,13,17-tris(2-methoxycarbonylethyl)-2,7,12,18-tetramethylporphyrin
There total 1 articles about 3-(2-chloroethyl)-8,13,17-tris(2-methoxycarbonylethyl)-2,7,12,18-tetramethylporphyrin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H23ClN2O2; 3-{5-Formyl-2-[5-formyl-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester;
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 20 ℃;
for 16h;
Darkness;
With
zinc diacetate;
In
methanol; dichloromethane;
for 10h;
With
sulfuric acid;
In
methanol;
for 14h;
Darkness;
DOI:10.1515/BC.2010.006
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: zinc diacetate / methanol; dichloromethane / 2 h / Darkness
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 72 h / Darkness
2.2: 14 h / Darkness
3.1: hydrogenchloride; water / 6 h / 20 °C
4.1: sodium amalgam; potassium hydroxide / 0.08 h / 80 °C / Darkness
5.1: recombinant oxygen-independent coproporphyrinogen III oxidase; S-Adenosyl-L-methionine; NADH; D,L-dithiothreitol / 1 h / 37 °C / pH 7 / Inert atmosphere; Bis-Tris buffer; Enzymatic reaction
5.2: 0.25 h / Bis-Tris buffer
With
hydrogenchloride; sodium amalgam; recombinant oxygen-independent coproporphyrinogen III oxidase; potassium tert-butylate; zinc diacetate; water; S-Adenosyl-L-methionine; NADH; potassium hydroxide; D,L-dithiothreitol;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1515/BC.2010.006
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: zinc diacetate / methanol; dichloromethane / 2 h / Darkness
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 72 h / Darkness
2.2: 14 h / Darkness
3.1: hydrogenchloride; water / 6 h / 20 °C
With
hydrogenchloride; potassium tert-butylate; zinc diacetate; water;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1515/BC.2010.006
