Technology Process of 2-(tert-butyl)-4,5-diphenylpyridine
There total 3 articles about 2-(tert-butyl)-4,5-diphenylpyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl isocyanide; 2,3-diphenyl-1,3-butadiene;
With
bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine;
In
toluene;
at 130 ℃;
for 48h;
Inert atmosphere;
In
toluene;
for 1h;
Reflux;
DOI:10.1021/ja208162w
- Guidance literature:
-
4,4-dimethyl-1-phenyl-1-penten-3-one; C14H23NSi;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; dimethyl sulfoxide;
at 20 ℃;
for 18h;
Inert atmosphere;
Molecular sieve;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dimethyl sulfoxide;
at 20 ℃;
for 1h;
regioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/acs.orglett.8b02703
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); magnesium / tetrahydrofuran / 48 h / Reflux; Inert atmosphere
2.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine / toluene / 48 h / 130 °C / Inert atmosphere
2.2: air / 1 h / Reflux
With
bis(1,5-cyclooctadiene)nickel (0); tetrakis(triphenylphosphine) palladium(0); magnesium; tricyclohexylphosphine;
In
tetrahydrofuran; toluene;
DOI:10.1021/ja208162w
