6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

Base Information

Chemical Name:6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine
CAS No.:1271802-33-5
Molecular Formula:C₂₄H₂₃N₇
Molecular Weight:409.494
Hs Code.:

Synonyms:6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

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Chemical Property of 6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

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Technology Process of 6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

There total 5 articles about 6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271808-85-5
C₂₃H₂₈N₄O₂

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1271802-33-5
6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: C₂₃H₂₈N₄O₂; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

Reference yield:

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 1271802-33-5
6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C

1.2: 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: triethylamine / tetrahydrofuran / 20 °C

4.2: 2 h / 60 °C

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

5.2: 4 h / 100 °C

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; n-heptane; ethylbenzene; water;

Reference yield:

: 180691-65-0
5-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1271802-33-5
6-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-phenyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

3.2: 2 h / 60 °C

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.2: 4 h / 100 °C

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;