5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Base Information

Chemical Name:5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine
CAS No.:1401345-11-6
Molecular Formula:C₂₀H₁₃FN₆O
Molecular Weight:372.361
Hs Code.:

Synonyms:5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

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Chemical Property of 5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

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Technology Process of 5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

There total 11 articles about 5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416240-26-0
5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

: 1401345-11-6
5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: With water; sodium hydroxide; In 1,4-dioxane; at 100 ℃; for 2h;

Reference yield:

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 1401345-11-6
5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 65 - 80 °C

2: hydrazine / ethanol / 12 h / Reflux

3: ethanol / 2 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux

5: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C

7: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 24 h / Reflux

9: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

10: sodium hydroxide; water / 1,4-dioxane / 2 h / 100 °C

With copper(l) iodide; water; iodine; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1401345-11-6
5-(3-(6-(4-fluorophenyl)pyrazin-2-yl)-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 24 h / Reflux

2: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

3: sodium hydroxide; water / 1,4-dioxane / 2 h / 100 °C

With water; potassium carbonate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;