Anisodinic acid

Base Information

• Chemical Name: Anisodinic acid
• CAS No.: 85700-56-7
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.176
• Mol file: 85700-56-7.mol

Synonyms:(S)-2,3-Dihydroxy-2-phenyl-propionic acid;S-(-)-α-phenylglyceric acid;

Chemical Property of Anisodinic acid

Chemical Property:

• Vapor Pressure: 1.13E-07mmHg at 25°C
• Boiling Point: 416.2°Cat760mmHg
• Flash Point: 219.7°C
• PSA: 77.76000
• Density: 1.409g/cm³
• LogP: -0.04890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Anisodinic acid

There total 3 articles about Anisodinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium R,S-α-phenylglycerate (98324-48-2) → (S)-2,3-dihydroxy-2-phenylpropanoic acid (85700-56-7)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/S0040-4020(01)96519-6

Reference yield:

potassium α-phenylglycidate (98324-46-0) → (S)-2,3-dihydroxy-2-phenylpropanoic acid (85700-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrolysis

2: conc. HCl / H₂O

With hydrogenchloride; In water;

DOI:10.1016/S0040-4020(01)96519-6

Reference yield:

(S)-5-Hydroxymethyl-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-one → (S)-2,3-dihydroxy-2-phenylpropanoic acid (85700-56-7)

Guidance literature:

With water; hydroxide; Heating;

DOI:10.1021/jo952021v

upstream raw materials:

potassium R,S-α-phenylglycerate

potassium α-phenylglycidate

Downstream raw materials:

methyl S-(-)-2,3-dihydroxy-2-phenylpropanoate

Refernces

• 1、 Whitman, Christian P.,Craig, J. Cymerman,Kenyon, George L.. "SYNTHESIS, CHIROPTICAL PROPERTIES AND ABSOLUTE CONFIGURATION OF α-PHENYLGLYCIDIC ACID". . p. 1183 - 1192. Retrieved 2007/10/02.