N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

Base Information

Chemical Name:N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine
CAS No.:1246087-81-9
Molecular Formula:C₂₂H₁₈ClFN₄O₂
Molecular Weight:424.862
Hs Code.:

N<SUP>4</SUP>-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

Synonyms:N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

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Chemical Property of N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

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Technology Process of N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

There total 16 articles about N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxy-6-nitroquinazolin-4-amine

: 1246087-81-9
N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

Guidance literature:: With iron; acetic acid; In ethanol; at 85 ℃;

Reference yield: 70.0%

: N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-methoxyquinazolin-6-yl)acetamide

: 1246087-81-9
N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

Guidance literature:: With hydrogenchloride; In methanol; at 70 ℃; for 24h;

Reference yield:

: 443882-99-3
3-chloro-4-(3-fluorobenzyloxy)nitrobenzene

: 1246087-81-9
N⁴-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-methoxyquinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; ammonium chloride / ethanol; water / 60 °C

2: isopropyl alcohol / 3 h / 60 °C

3: iron; acetic acid / ethanol / 85 °C

With iron; ammonium chloride; acetic acid; zinc; In ethanol; water; isopropyl alcohol;