3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester

Base Information

• Chemical Name: 3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester
• CAS No.: 1378523-88-6
• Molecular Formula: C₂₂H₂₁NO₄S
• Molecular Weight: 395.479
• Mol file: 1378523-88-6.mol

Synonyms:3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester

Chemical Property of 3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester

There total 1 articles about 3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tosyl-(S)-phenylalanine (13505-32-3) + propargyl bromide (106-96-7) → 3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester (1378523-88-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 - 70 ℃; for 4h;

DOI:10.1021/ol301219c

Reference yield:

3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester (1378523-88-6) → N-(1-(hydroxymethyl)-2-phenylethyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide (1378523-77-3)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; ethanol; at 5 - 28 ℃; for 1h;

DOI:10.1021/ol301219c

Reference yield:

3-phenyl-2-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester (1378523-88-6) → (S)-4-methyl-N-(1-oxo-3-phenylpropan-2-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide (1232168-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 5 - 28 °C

2: pyridinium chlorochromate / dichloromethane / 6 h / 10 - 28 °C

With lithium borohydride; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/ol301219c

upstream raw materials:

N-tosyl-(S)-phenylalanine

propargyl bromide

Downstream raw materials:

(S)-4-methyl-N-(1-oxo-3-phenylpropan-2-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

3-benzyl-6-methyl-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-[1,4]oxazine

C₂₆H₂₇NO₄S

3-benzyl-2-(4-methoxyphenyl)-6-methyl-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-[1,4]oxazine