<5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...

Base Information

• Chemical Name: <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...
• CAS No.: 164118-33-6
• Molecular Formula: C₆₈H₈₄O₁₄Si
• Molecular Weight: 1153.49

Synonyms:<5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...

Chemical Property of <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...

There total 20 articles about <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

triethylsilyl trifluoromethyl sulfonate (79271-56-0) + <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmet... (164118-30-3) → <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano... (164118-33-6)

Guidance literature:

With pyridine; In dichloromethane; at 22 ℃; for 0.166667h;

Reference yield:

<2(4S,5R)>-2-<5-Methyl-4-<oxy>-3-methylene-6-phenylhexyl>-1,3-dithiane (162107-31-5) → <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano... (164118-33-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 40 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -25 deg C, 1.5 h, 2.) -78 deg C, 5 min

2: 99 percent / 2percent HCl / methanol; CH₂Cl₂ / 0.08 h / 22 °C

3: 83 percent / CaCO₃, aq. Hg(ClO₄)2 / tetrahydrofuran / 2.5 h / 22 °C

4: 45 percent / 2percent HCl / 21 h / 78 °C

5: 30 percent / 49percent aq. HF / nitromethane / 24 h / 0 °C

6: LiOH*H₂O / tetrahydrofuran; H₂O / 1 h / 22 °C

7: tetrahydrofuran / 1.5 h / 55 °C

8: 21 percent / CSA / CH₂Cl₂ / 0.75 h / 22 °C

9: DMAP, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 10.5 h / 22 °C

10: 79 percent / pyridine / CH₂Cl₂ / 0.17 h / 22 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; n-butyllithium; mercury(II) perchlorate; camphor-10-sulfonic acid; hydrogen fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; calcium carbonate; In tetrahydrofuran; methanol; nitromethane; hexane; dichloromethane; water;

Reference yield:

<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane (164118-43-8) → <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano... (164118-33-6)

Guidance literature:

Multi-step reaction with 13 steps

1: 64 percent / DIBALH / CH₂Cl₂; benzene / 1.) 0 deg C, 10 min, 2.) 22 deg C, 20 h

2: 70 percent / DDQ / CH₂Cl₂; H₂O / 0.5 h / 22 °C

3: 87 percent / 2,6-lutidine, DMAP / 8 h / 70 °C

4: 40 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -25 deg C, 1.5 h, 2.) -78 deg C, 5 min

5: 99 percent / 2percent HCl / methanol; CH₂Cl₂ / 0.08 h / 22 °C

6: 83 percent / CaCO₃, aq. Hg(ClO₄)2 / tetrahydrofuran / 2.5 h / 22 °C

7: 45 percent / 2percent HCl / 21 h / 78 °C

8: 30 percent / 49percent aq. HF / nitromethane / 24 h / 0 °C

9: LiOH*H₂O / tetrahydrofuran; H₂O / 1 h / 22 °C

10: tetrahydrofuran / 1.5 h / 55 °C

11: 21 percent / CSA / CH₂Cl₂ / 0.75 h / 22 °C

12: DMAP, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 10.5 h / 22 °C

13: 79 percent / pyridine / CH₂Cl₂ / 0.17 h / 22 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; lithium hydroxide; n-butyllithium; mercury(II) perchlorate; camphor-10-sulfonic acid; hydrogen fluoride; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium carbonate; In tetrahydrofuran; methanol; nitromethane; hexane; dichloromethane; water; benzene;

upstream raw materials:

triethylsilyl trifluoromethyl sulfonate

(7S)-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmethyl ester

(2E,4S,6S)-4,6-dimethyl-2-octenoic acid

<5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmet...

Downstream raw materials:

<5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmethyl ester

zaragozic acid A

(E,4S,6S)-4,6-Dimethyl-2-octenoic acid benzyl ester

<5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 164118-33-6 <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-11-O-<(4-methoxyphenyl)methyl>-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-6-O-(triethylsilyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furano...

Send

Send

Metric Ton KG G Pound L ML

Send

Send