N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

Base Information

Chemical Name:N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide
CAS No.:1327167-21-4
Molecular Formula:C₂₇H₂₇ClN₆O₃S
Molecular Weight:551.069
Hs Code.:

Synonyms:N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

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Chemical Property of N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

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Technology Process of N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

There total 5 articles about N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345733-04-1
C₂₁H₂₄N₆O

: 2888-06-4
3-chlorophenylsulfonyl chloride

: 1327167-21-4
N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

Guidance literature:: With pyridine; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.06.016

Reference yield:

: 401495-67-8
4-(4-methylpiperazin-4-ium-1-yl)benzoyl chloride

: 1327167-21-4
N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1 h / 20 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 12 h / 20 °C

3: pyridine / dimethyl sulfoxide / 1 h / 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.06.016

Reference yield:

: C₂₁H₂₂N₆O₃

: 1327167-21-4
N-[3-(3-[(3-chlorophenyl)sulfonyl]aminophenyl)-1H-pyrazol-5-yl]-4-(4-methylpiperazino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 12 h / 20 °C

2: pyridine / dimethyl sulfoxide / 1 h / 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.06.016