Technology Process of trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2.3-c]pyridin-4-yl]-1H-pyrazol-1-yl}cyclohexanol
There total 5 articles about trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2.3-c]pyridin-4-yl]-1H-pyrazol-1-yl}cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3-benzothiadiazole; 4-{1-[4-(tert-butyl-dimethylsilanyloxy)cyclohexyl]-1H-pyrazol-4-yl}-2-chlorofuro[2,3-c]pyridin-7-ylamine;
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 110 ℃;
for 1h;
Microwave irradiation;
With
hydrogenchloride;
In
1,4-dioxane; methanol; water;
at 30 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water; tetrahydrofuran / 0.5 h / 20 °C
2.1: potassium nitrate; sulfuric acid / 16.5 h / 10 - 20 °C
2.2: 1 h / Reflux
3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 - 30 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 95 °C
5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation
5.2: 0.5 h / 30 °C
With
hydrogenchloride; tert.-butylnitrite; sulfuric acid; potassium acetate; potassium carbonate; potassium nitrate; copper(ll) bromide; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium nitrate; sulfuric acid / 16.5 h / 10 - 20 °C
1.2: 1 h / Reflux
2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 - 30 °C
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 95 °C
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation
4.2: 0.5 h / 30 °C
With
tert.-butylnitrite; sulfuric acid; potassium acetate; potassium carbonate; potassium nitrate; copper(ll) bromide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water; acetonitrile;
