2-(3-Methoxyphenyl)quinoxaline

Base Information

• Chemical Name: 2-(3-Methoxyphenyl)quinoxaline
• CAS No.: 71897-08-0
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.273
• DSSTox Substance ID: DTXSID901305525
• Nikkaji Number: J2.341.419H
• Mol file: 71897-08-0.mol

Synonyms:2-(3-methoxyphenyl)quinoxaline;2-(3-methoxylphenyl)quinoxaline;DTXSID901305525;71897-08-0

Chemical Property of 2-(3-Methoxyphenyl)quinoxaline

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 236.094963011
• Heavy Atom Count: 18
• Complexity: 271

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2

Technology Process of 2-(3-Methoxyphenyl)quinoxaline

There total 17 articles about 2-(3-Methoxyphenyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tris-(3-methoxy-phenyl)-bismuthane (95149-16-9) + 2-chloroquinoxaline (1448-87-9) → 2-(3-methoxyphenyl)quinoxaline (71897-08-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; Inert atmosphere; Sealed tube;

DOI:10.1002/ejoc.201300850

Reference yield: 94.0%

2-bromo-3'-methoxyacetophenone (5000-65-7) + 1,2-diamino-benzene (95-54-5) → 2-(3-methoxyphenyl)quinoxaline (71897-08-0)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 20 ℃; for 5h;

DOI:10.1039/c6ra03078e

Reference yield: 92.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-(3-methoxylphenyl)ethan-1-one + 1,2-diamino-benzene (95-54-5) → 2-(3-methoxyphenyl)quinoxaline (71897-08-0)

Guidance literature:

With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate; In dichloromethane; at 60 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.202000411

upstream raw materials:

2-(3-hydroxyphenyl)quinoxaline

dimethyl sulfate

1-(3-methoxyphenyl)-1,2-ethanediol

1,2-diamino-benzene

Downstream raw materials:

(S)-2-(3-methoxyphenyl)-1,2,3,4-tetrahydroquinoxaline

2-(5-methoxy-2-nitrophenyl)quinoxaline

2-(dimethoxymethyl)-3-(3-methoxyphenyl)quinoxaline